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Journal of Neurodevelopmental Disorders

, Volume 1, Issue 3, pp 205–214

First Online: 04 April 2009Received: 05 January 2009Accepted: 06 March 2009

Abstract

Purpose: determine if language disorder in children with autistic disorder AD corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. Methods: MRI morphometric study in children with AD n = 50 to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale PT, which is larger in the left hemisphere in most healthy individuals. Results: i Heschl’s gyrus and planum polare showed typical hemisphere asymmetry patterns; ii posterior Superior Temporal Gyrus pSTG showed significant rightward asymmetry; and iii PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys n = 30. For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. Conclusions: results provide evidence for rightward asymmetry in auditory association areas pSTG and PT known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry.

KeywordsAuditory cortex Developmental disorder Heschl’s gyrus Language cortex Posterior superior temporal gyrus Electronic supplementary materialThe online version of this article doi:10.1007-s11689-009-9010-2 contains supplementary material, which is available to authorized users.

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Author: Nicole M. Gage - Jenifer Juranek - Pauline A. Filipek - Kathryn Osann - Pamela Flodman - A. Lisette Isenberg - M. Anne 

Source: https://link.springer.com/







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