DNA deaminases: AIDing hormones in immunity and cancerReport as inadecuate




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Journal of Molecular Medicine

, Volume 87, Issue 9, pp 893–897

First Online: 25 June 2009Received: 11 May 2009Revised: 03 June 2009Accepted: 08 June 2009

Abstract

It is well established that hormones can cause cancer, much less known is how they induce this change in our somatic cells. This review highlights the recent finding that estrogen can exert its DNA-damaging potential by directly activating DNA deaminases. This recently discovered class of proteins deaminate cytosine to uracil in DNA, and are essential enzymes in the immune system. The enhanced production of a given DNA deaminase, induced by estrogen, can lead not only to a more active immune response, but also to an increase in mutations and oncogenic translocations. Identifying the direct molecular link between estrogen and a mutation event provides us with new targets for studying and possibly inhibiting the pathological side-effects of estrogen.

KeywordsHormones DNA mutations Cancer AID APOBEC3 Autoimmunity  Download fulltext PDF



Author: Svend K. Petersen-Mahrt - Heather A. Coker - Siim Pauklin

Source: https://link.springer.com/



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