A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorderReport as inadecuate




A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder - Download this document for free, or read online. Document in PDF available to download.

Journal of Neurodevelopmental Disorders

, Volume 1, Issue 3, pp 215–223

First Online: 14 May 2009Received: 28 January 2009Accepted: 29 March 2009

Abstract

Autism Spectrum Disorder ASD is associated with both i post-mortem and neuroimaging evidence of abnormal cortical development, and ii altered signalling in Brain Derived Neurotrophic Factor BDNF pathways - which regulate neuroproliferative and neuroplastic processes. In healthy controls genotype at a single nucleotide polymorphism that alters BDNF signalling Val66met has been related to regional cortical volume. It is not known however if this influence on brain development is intact in ASD. Therefore we compared the relationship between genotype and cortical anatomy as measured using in vivo Magnetic Resonance Imaging in 41 people with ASD and 30 healthy controls. We measured cortical volume, and its two sole determinants - cortical thickness and surface area - which reflect differing neurodevelopmental processes. We found -Group-by-Genotype- interactions for cortical volume in medial caudal anterior cingulate, posterior cingulate and lateral rostral middle, lateral orbitofrontal, pars orbitalis and pars triangularis frontal cortices. Furthermore, within only these regions -Group-by-Genotype- interactions were also found for surface area. No effects were found for cortical thickness in any region. Our preliminary findings suggest that people with ASD have differences from controls in the relationship between BDNF val66met genotype and regional especially frontal cortical volume and surface area, but not cortical thickness. Therefore alterations in the relationship between BDNF val66met genotype and surface area in ASD may drive the findings for volume. If correct, this suggests ASD is associated with a distorted relationship between BDNF val66met genotype and the determinants of regional cortical surface area – gyrification and-or sulcal positioning.

KeywordsAutism Brain Brain derived neurotrophic factor MRI  Download fulltext PDF



Author: Armin Raznahan - Roberto Toro - Petra Proitsi - John Powell - Tomas Paus - Patrick F. Bolton - Declan G. M. Murphy

Source: https://link.springer.com/







Related documents