HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.Report as inadecuate




HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Rétrovirus et Transfert Génétique 2 IDM - LUTI - IDM Laboratoire Universitaire de Transfert en Immunologie Luti 3 Department of Molecular Cell Biology

Abstract : DC-SIGN, a dendritic cell DC-specific lectin, mediates clustering of DCs with T lymphocytes, a crucial event in the initiation of immune responses. DC-SIGN also binds HIV envelope glycoproteins, allowing efficient virus capture by DCs. We show here that DC-SIGN surface levels are upregulated in HIV-1-infected DCs. This process is caused by the viral protein Nef, which acts by inhibiting DC-SIGN endocytosis. Upregulation of DC-SIGN at the cell surface dramatically increases clustering of DCs with T lymphocytes and HIV-1 transmission. These results provide new insights into how HIV-1 spreads from DCs to T lymphocytes and manipulates immune responses. They help explain how Nef may act as a virulence factor in vivo.





Author: Nathalie Sol-Foulon - Arnaud Moris - Cinzia Nobile - Claire Boccaccio - Anneke Engering - Jean-Pierre Abastado - Jean-Michel Hear

Source: https://hal.archives-ouvertes.fr/



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