The mosaic of KIR haplotypes in rhesus macaquesReport as inadecuate




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Immunogenetics

, Volume 62, Issue 5, pp 295–306

First Online: 05 March 2010Received: 22 December 2009Accepted: 08 February 2010

Abstract

To further refine and improve biomedical research in rhesus macaques, it is necessary to increase our knowledge concerning both the degree of allelic variation polymorphism and diversity gene copy number variation in the killer cell immunoglobulin-like receptor KIR gene cluster. Pedigreed animals in particular should be studied, as segregation data will provide clues to the linkage of particular KIR genes-alleles segregating on a haplotype and to its gene content as well. A dual strategy allowed us to screen the presence and absence of genes and the corresponding transcripts, as well as to track differences in transcription levels. On the basis of this approach, 14 diverse KIR haplotypes have been described. These haplotypes consist of multiple inhibitory and activating Mamu-KIR genes, and any gene present on one haplotype may be absent on another. This suggests that the cost of accelerated evolution by recombination may be the loss of certain framework genes on a haplotype.

KeywordsNatural killer cells MHC Comparative immunology Evolution KIR  Download fulltext PDF



Author: Jeroen H. Blokhuis - Marit K. van der Wiel - Gaby G. M. Doxiadis - Ronald E. Bontrop

Source: https://link.springer.com/







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