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Cancer Cell International

, 10:23

First Online: 08 July 2010Received: 24 May 2010Accepted: 08 July 2010

Abstract

Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion-s share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2867-10-23 contains supplementary material, which is available to authorized users.

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Author: Shyam Nyati - Brian D Ross - Alnawaz Rehemtulla - Mahaveer S Bhojani

Source: https://link.springer.com/







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