DHA Metabolism: Targeting the Brain and LipoxygenationReport as inadecuate




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Molecular Neurobiology

, Volume 42, Issue 1, pp 48–51

First Online: 28 April 2010Received: 05 April 2010Accepted: 05 April 2010

Abstract

Docosahexaenoic acid DHA, the end-product of the metabolism of omega-3 family fatty acids, is the main polyunsaturated fatty acid of the brain, but its accumulation is incompletely understood. This paper reviews how it could accumulate through specific uptake of DHA-containing lysophosphatidylcholine LysoPC-DHA. DHA migrates very easily from the sn-2 position of LysoPC, which could be considered as the physiological form of polyunsaturated LysoPC, to the sn-1 position, which is much more stable. An approach preventing migration by acetylating the sn-1 position, while retaining the main physico-chemical properties of the carrier, is described. Also, the double lipoxygenation and bond-isomerization of DHA into 10S,17S-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described. As in other E,Z,E conjugated trienes, PDX is shown to inhibit human blood platelet aggregation at submicromolar concentrations.

KeywordsDHA Lysophosphatidylcholine PDX  Download fulltext PDF



Author: M. Picq - P. Chen - M. Perez - M. Michaud - E. Véricel - M. Guichardant - M. Lagarde

Source: https://link.springer.com/







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