TGFβ-1 and TGFBR2 polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese nonsmoking females: a case control studyReport as inadecuate




TGFβ-1 and TGFBR2 polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese nonsmoking females: a case control study - Download this document for free, or read online. Document in PDF available to download.

BMC Medical Genetics

, 16:22

Genetic epidemiology and genetic associations

Abstract

BackgroundTransforming growth factor-β TGF-β plays an important role in regulating cellular functions, and many studies have demonstrated important roles for TGF-β in various cancers. Single nucleotide polymorphisms SNPs of TGF-β may influence lung carcinogenesis. The aim of this study was to test whether TGF-β1 C509T and TGF-β receptor II TGFBR2 G-875A polymorphisms were associated with lung adenocarcinoma in nonsmoking females.

MethodsA hospital-based case–control study was performed in Chinese nonsmoking females. Genotyping was performed using TaqMan SNP genotyping assay, and demographic data and environmental exposure were collected by trained interviewers after informed consents were obtained.

ResultsA total of 272 95.4% cases and 313 99.4% controls were successfully genotyped, and the results showed that the polymorphic allele frequencies of C509T and G875A were similar among lung adenocarcinoma patients and controls P=0.589 and 0.643, respectively. However, when the data were stratified for cooking oil fume exposure, the TT genotype of the TGFB1 C509T polymorphism showed a significantly decreased risk for lung adenocarcinoma compared with the CC genotype adjusted OR=0.362, 95% CI=0.149–0.878, P=0.025.

ConclusionsTGF-β1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism.

KeywordsTransforming growth factor-β Lung adenocarcinoma Polymorphisms Nonsmoking females AbbreviationsSNPsSingle nucleotide polymorphisms

TGFB1Transforming growth factor-β1

TGFBR2Transforming growth factor receptorII

OROdds ratio

CIConfidence interval

BaPBenzoapyrene

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Author: Yangwu Ren - Zhihua Yin - Kun Li - Yan Wan - Xuelian Li - Wei Wu - Peng Guan - Baosen Zhou

Source: https://link.springer.com/







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