The Role of Glia in Alpha-SynucleinopathiesReport as inadecuate




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Molecular Neurobiology

, Volume 47, Issue 2, pp 575–586

First Online: 02 September 2012Received: 20 August 2012Accepted: 20 August 2012

Abstract

α-Synuclein AS-positive inclusions are the pathological hallmark of Parkinson’s disease PD, dementia with Lewy bodies DLB and multiple system atrophy MSA, all belonging to the category of α-synucleinopathies. α-Synucleinopathies represent progressive neurodegenerative disorders characterised by increasing incidences in the population over the age of 65. The relevance of glial reactivity and dysfunction in α-synucleinopathies is highlighted by numerous experimental evidences. Glial AS inclusion pathology is prominent in oligodendroglia of MSA glial cytoplasmic inclusions and is a common finding in astroglial cells of PD and DLB, resulting in specific dysfunctional responses. Involvement of AS-dependent astroglial and microglial activation in neurodegenerative mechanisms, and therefore in disease initiation and progression, has been suggested. The aim of this review is to summarise and discuss the multifaceted responses of glial cells in α-synucleinopathies. The beneficial, as well as detrimental, effects of glial cells on neuronal viability are taken into consideration to draw an integrated picture of glial roles in α-synucleinopathies. Furthermore, an overview on therapeutic approaches outlines the difficulties of translating promising experimental studies into successful clinical trials targeting candidate glial pathomechanisms.

Keywordsα-Synuclein Astroglia Microglia Multiple system atrophy Oligodendroglia Parkinson’s disease  Download fulltext PDF



Author: Lisa Fellner - Nadia Stefanova

Source: https://link.springer.com/







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