Anti-Yo Associated Paraneoplastic Cerebellar Degeneration in a Man with Large Cell Cancer of the LungReport as inadecuate




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Case Reports in Neurological MedicineVolume 2013 2013, Article ID 725936, 5 pages

Case Report

Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

Department of Internal Medicine, University of Illinois Urbana-Champaign, 611 W. Park Street, Urbana, IL 61801, USA

Department of Neurology, University of Illinois Urbana-Champaign, 611 W. Park Street, Urbana, IL 61801, USA

Received 2 August 2013; Accepted 25 August 2013

Academic Editors: G. Galassi and B. Smith

Copyright © 2013 Linda Hasadsri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purkinje cell cytoplasmic antibody type 1 PCA-1, or anti-Yo, is the most frequently detected autoantibody in paraneoplastic cerebellar degeneration PCD. The vast majority of cases of anti-Yo PCD, however, occur in females over 60 years old and are associated with gynecologic tumors. Only 10 cases have been reported in males, and only 2 were associated with cancer of the lung. Here we describe the youngest known case of PCA-1 positive PCD in a male, whose lung tumor was undetectable even on FDG-PET.





Author: Linda Hasadsri, James Lee, Bonnie H. Wang, Lalitha Yekkirala, and Mingtao Wang

Source: https://www.hindawi.com/



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