Oral squamous cell carcinoma in relation to field precancerisation: pathobiologyReport as inadecuate




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Cancer Cell International

, 13:31

First Online: 03 April 2013Received: 18 January 2013Accepted: 20 March 2013

Abstract

Squamous cell carcinoma of the oral cavity evolves within a field of precancerized oral epithelium containing keratinocytes at different stages of transformation. Following acquisition of additional genetic alterations, these precancerous keratinocytes may become cancerous.

Persons with apparently successfully treated oral squamous cell carcinoma are at high risk of developing a new carcinoma at, or close to the site of the treated tumour. This second carcinoma may have developed either from malignant keratinocytes left behind at surgery recurrence, or from transformed keratinocytes within the field of precancerized epithelium from which the primary carcinoma had arisen new carcinoma.

The cells of the new carcinoma may have genetic changes in common with the cells of the original carcinoma because both are descended from a proliferating monoclone within the precancerized field; but if the new cancer originates from a different clone, it may have a dissimilar genetic profile even if the original and the new carcinoma are closely contiguous.

The purpose of this article is to review the pathobiology of oral squamous cell carcinoma in relation to fields of precancerised oral epithelium.

KeywordsField precancerisation Oral squamous cell carcinoma Electronic supplementary materialThe online version of this article doi:10.1186-1475-2867-13-31 contains supplementary material, which is available to authorized users.

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Author: Liviu L Feller - Razia RAG Khammissa - Beverly B Kramer - Johan J Lemmer

Source: https://link.springer.com/



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