Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane spaceReport as inadecuate




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Cell and Tissue Research

, Volume 367, Issue 1, pp 43–57

First Online: 08 September 2016Received: 02 June 2016Accepted: 05 August 2016

Abstract

Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron-sulfur cluster biogenesis, respiration and apoptosis. Here, we describe briefly the various protein import pathways for sorting of mitochondrial proteins into the different subcompartments, with an emphasis on the targeting to the intermembrane space. The discovery of a dedicated redox-controlled pathway in the intermembrane space that links protein import to oxidative protein folding raises important questions on the redox regulation of this process. We discuss the salient features of redox regulation in the intermembrane space and how such mechanisms may be linked to the more general redox homeostasis balance that is crucial not only for normal cell physiology but also for cellular dysfunction.

KeywordMitochondria Protein import Intermembrane space Redox regulation Oxidative folding  Download fulltext PDF



Author: Phanee Manganas - Lisa MacPherson - Kostas Tokatlidis

Source: https://link.springer.com/







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