Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorderReport as inadecuate




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Journal of Neurodevelopmental Disorders

, 9:1

First Online: 17 January 2017Received: 15 July 2016Accepted: 04 January 2017

Abstract

BackgroundDisruptive behavior in autism spectrum disorder ASD is an important clinical problem, but its neural basis remains poorly understood. The current research aims to better understand the neural underpinnings of disruptive behavior in ASD, while addressing whether the neural basis is shared with or separable from that of core ASD symptoms.

MethodsParticipants consisted of 48 male children and adolescents: 31 ASD 7 had high disruptive behavior and 17 typically developing TD controls, well-matched on sex, age, and IQ. For ASD participants, autism symptom severity, disruptive behavior, anxiety symptoms, and ADHD symptoms were measured. All participants were scanned while viewing biological motion BIO and scrambled motion SCR. Two fMRI contrasts were analyzed: social perception BIO > SCR and Default Mode Network DMN deactivation fixation > BIO. Age and IQ were included as covariates of no interest in all analyses.

ResultsFirst, the between-group analyses on BIO > SCR showed that ASD is characterized by hypoactivation in the social perception circuitry, and ASD with high or low disruptive behavior exhibited similar patterns of hypoactivation. Second, the between-group analyses on fixation > BIO showed that ASD with high disruptive behavior exhibited more restricted and less DMN deactivation, when compared to ASD with low disruptive behavior or TD. Third, the within-ASD analyses showed that a autism symptom severity but not disruptive behavior was uniquely associated with less activation in the social perception regions including the posterior superior temporal sulcus and inferior frontal gyrus; b disruptive behavior but not autism symptom severity was uniquely associated with less DMN deactivation in the medial prefrontal cortex MPFC and lateral parietal cortex; and c anxiety symptoms mediated the link between disruptive behavior and less DMN deactivation in both anterior cingulate cortex ACC and MPFC, while ADHD symptoms mediated the link primarily in ACC.

ConclusionsIn boys with ASD, disruptive behavior has a neural basis in reduced DMN deactivation, which is distinct and separable from that of core ASD symptoms, with the latter characterized by hypoactivation in the social perception circuitry. These differential neurobiological markers may potentially serve as neural targets or predictors for interventions when treating disruptive behavior vs. core symptoms in ASD.

KeywordsAutism spectrum disorder Comorbidity Neuroimaging Social perception Disruptive behavior Oppositional defiant disorder Anxiety disorders ADHD Default mode network AbbreviationsACCAnterior cingulate cortex

ADHDAttention-deficit-hyperactivity disorder

ADI-RAutism Diagnostic Interview-Revised

ADOSAutism Diagnostic Observation Schedule

ASDAutism spectrum disorder

BIOBiological motion

CDTCluster-defining threshold

DMNDefault mode network

FFGFusiform gyrus

GLMGeneral linear model

IFGInferior frontal gyrus

IQIntelligence quotient

LPCLateral parietal cortex

MPFCMedial prefrontal cortex

ODDOppositional defiant disorder

pSTSPosterior superior temporal sulcus

SCRScrambled motion

SRSSocial Responsiveness Scale

TDTypically developing

Electronic supplementary materialThe online version of this article doi:10.1186-s11689-017-9183-z contains supplementary material, which is available to authorized users.

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Author: Y. J. Daniel Yang - Denis G. Sukhodolsky - Jiedi Lei - Eran Dayan - Kevin A. Pelphrey - Pamela Ventola

Source: https://link.springer.com/







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