Voluntary control of intracortical oscillations for reconfiguration of network activityReport as inadecuate




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1 UPMC - Université Pierre et Marie Curie - Paris 6 2 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute 3 Universidad de los Andes Bogota 4 Center for NeuroImaging Research - CENIR 5 Centre de référence des épilepsies rares CHU Pitié-Salpêtrière 6 Service de Neurochirurgie CHU Pitié-Salpêtrière

Abstract : Voluntary control of oscillatory activity represents a key target in the self-regulation of brain function. Using a real-time closed-loop paradigm and simultaneous macro- and micro-electrode recordings, we studied the effects of self-induced intracortical oscillatory activity 4–8 Hz in seven neurosurgical patients. Subjects learned to robustly and specifically induce oscillations in the target frequency, confirmed by increased oscillatory event density. We have found that the session-to-session variability in performance was explained by the functional long-range decoupling of the target area suggesting a training-induced network reorganization. Downstream effects on more local activities included progressive cross-frequency-coupling with gamma oscillations 30–120 Hz, and the dynamic modulation of neuronal firing rates and spike timing, indicating an improved temporal coordination of local circuits. These findings suggest that effects of voluntary control of intracortical oscillations can be exploited to specifically target plasticity processes to reconfigure network activity, with a particular relevance for memory function or skill acquisition.





Author: Juliana Corlier - Mario Valderrama - Miguel Navarrete - Katia Lehongre - Dominique Hasboun - Claude Adam - Hayat Belaid - Stépha

Source: https://hal.archives-ouvertes.fr/



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