Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infectionReport as inadecuate




Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection - Download this document for free, or read online. Document in PDF available to download.

Retrovirology

, 12:66

First Online: 30 July 2015Received: 24 March 2015Accepted: 16 July 2015

Abstract

BackgroundIt is well established that effector T cell responses are crucial for the control of most virus infections, but they are often tightly controlled by regulatory T cells Treg to minimize immunopathology. NK cells also contribute to virus control but it is not known if their antiviral effect is influenced by virus-induced Tregs as well. We therefore analyzed whether antiretroviral NK cell functions are inhibited by Tregs during an acute Friend retrovirus infection of mice.

ResultsSelective depletion of Tregs by using the transgenic DEREG mouse model resulted in improved NK cell proliferation, maturation and effector cell differentiation. Suppression of NK cell functions depended on IL-2 consumption by Tregs, which could be overcome by specific NK cell stimulation with an IL-2-anti-IL-2 mAb complex.

ConclusionsThe current study demonstrates that virus-induced Tregs indeed inhibit antiviral NK cell responses and describes a targeted immunotherapy that can abrogate the suppression of NK cells by Tregs.

KeywordsNK cells Friend retrovirus Regulatory T cells IL-2 consumption Treg suppression Electronic supplementary materialThe online version of this article doi:10.1186-s12977-015-0191-3 contains supplementary material, which is available to authorized users.

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Author: Elisabeth Littwitz-Salomon - Ilseyar Akhmetzyanova - Cecilia Vallet - Sandra Francois - Ulf Dittmer - Kathrin Gibbert

Source: https://link.springer.com/article/10.1186/s12977-015-0191-3



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