Primary osteomyelitis caused by an NDM-1-producing K. pneumoniae strain of the highly virulent sequence type 23Report as inadecuate




Primary osteomyelitis caused by an NDM-1-producing K. pneumoniae strain of the highly virulent sequence type 23 - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Structures bactériennes impliquées dans la modulation de la résistance aux antibiotiques 2 HEGP - Hôpital Européen Georges Pompidou APHP 3 UPD5 - Université Paris Descartes - Paris 5 4 CIMI - Centre d-Immunologie et de Maladies Infectieuses 5 INSERM - Institut National de la Santé et de la Recherche Médicale 6 Service de microbiologie CHU Saint-Antoine

Abstract : Hypervirulent variant of Klebsiella pneumoniae hvKP is characterized by its hypermucoviscosity and its capacity to cause invasive community-acquired infections in previously healthy young individuals. The most common clinical presentation is a pyogenic liver abscess with metastatic spread, while various other invasive infections have been reported. Strains of hvKP belong predominantly to the capsular serotypes K1 and K22 and their genetic background seems to differ from that of multidrug-resistant MDR isolates. The most commonly encountered sequence types STs among hvKP include ST23 associated with serotype K1, ST25, ST65, ST86, ST375 and the recently emerging ST380.





Author: Fabrice Compain - Alexis Vandenberghe - Marie Gominet - Nathalie Genel - David Lebeaux - Astrid Ramahefasolo - Isabelle Podglajen

Source: https://hal.archives-ouvertes.fr/



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