FGFR Family Members Protein Expression as Prognostic Markers in Oral Cavity and Oropharyngeal Squamous Cell CarcinomaReport as inadecuate




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Molecular Diagnosis and Therapy

, Volume 20, Issue 4, pp 363–374

First Online: 09 June 2016

Abstract

IntroductionFibroblast growth factor receptor family member proteins FGFR1–4 have been identified as promising novel therapeutic targets and prognostic markers in a wide spectrum of solid tumors. The present study investigates the expression and prognostic value of four FGFR family member proteins in a large multicenter oral cavity squamous cell carcinoma OCSCC and oropharyngeal squamous cell carcinoma OPSCC cohort.

MethodsProtein expression of FGFR1–4 was determined by immunohistochemistry on tissue microarrays containing 951 formalin-fixed paraffin embedded OCSCC and OPSCC tissues from the University Medical Center Utrecht and University Medical Center Groningen. Protein expression was correlated to overall survival using Cox regression models, and bootstrapping was performed as internal validation.

ResultsFGFR proteins were highly expressed in 39–64 % of OCSCC and 63–79 % of OPSCC. Seventy-three percent 299-412 of OCSCC and 85 % 305-357 of OPSCC highly co-expressed two or more FGFR family member proteins. FGFR1 protein was more frequently highly expressed in human papillomavirus HPV-negative OPSCC than HPV-positive OPSCC 82 vs. 65 %; p = 0.008. Furthermore, protein expression of FGFR family members was not related to overall survival in OCSCC or OPSCC p > 0.05.

ConclusionFGFR family members are frequently highly expressed in OCSCC and OPSCC. These FGFR family member proteins are therefore potential targets for novel therapies that are urgently required to improve survival of OCSCC and OPSCC patients.

Electronic supplementary materialThe online version of this article doi:10.1007-s40291-016-0204-5 contains supplementary material, which is available to authorized users.

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Author: Koos Koole - Martijn J. A. M. Clausen - Robert J. J. van Es - Pauline M. W. van Kempen - Lieuwe J. Melchers - Ron 

Source: https://link.springer.com/article/10.1007/s40291-016-0204-5







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