Effect of glucose concentration on peritoneal inflammatory cytokines in continuous ambulatory peritoneal dialysis patientsReport as inadecuate




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Mediators of Inflammation - Volume 13 2004, Issue 2, Pages 119-121



Division of Nephrology, Department of Internal Medicine, Yuzuncu Yil University, Tıp Fakültesi, İç Hastalıkları A.D., Nefroloji B.D., Van 65200, Turkey

Division of Rheumatology, Department of Internal Medicine, Yuzuncu Yil University, Tıp Fakültesi, İç Hastalıkları A.D., Nefroloji B.D., Van 65200, Turkey

Department of Biochemistry, Yuzuncu Yil University, Tıp Fakültesi, İç Hastalıkları A.D., Nefroloji B.D., Van 65200, Turkey



Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

OBJECTIVE: It is known that glucose concentrations of peritoneal dialysis solutions are detrimental to the peritoneal membrane. In order to determine the effect of glucose concentration on cytokine levels of peritoneal fluid of continuous ambulatory peritoneal dialysis CAPD patients, a cross-sectional study was performed.

Methods: Nine non-diabetic CAPD patients participated in two 8-h dwell sessions of overnight exchanges in consecutive days, with 1.36% and 3.86% glucose containing peritoneal dialysis solutions Baxter-Eczacıbaşı. Peritoneal dialysis fluid tumor necrosis factor TNF-α and interleukin IL-6 levels were measured.

Results: TNF-α levels after 1.36% and 3.86% glucose used dwells were 23±14 pg-ml and 28±4 pg-ml, respectively p=0.78. The IL-6 levels were 106±57 pg-ml and 115±63 pg-ml p=0.81, respectively.

Conclusion: In our in vivo study we found that the glucose concentration of the conventional lactate-based CAPD solution has no effect on basal IL-6 and TNF-α levels of peritoneal fluid. Further in vivo studies with non-lactate-based CAPD solutions are needed in order to determine the effect of glucose concentration per se on cytokine release.





Author: Hayriye Sayarlioglu, Cevat Topal, Mehmet Sayarlioglu, Haluk Dulger, Ekrem Dogan, and Reha Erkoc

Source: https://www.hindawi.com/



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