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BMC Psychiatry

, 7:32

First Online: 17 July 2007Received: 06 March 2007Accepted: 17 July 2007

Abstract

BackgroundAlthough major depression MD is associated with high levels of disability, the relationships between cognitive dysfunction and self-rated disability are poorly understood. This study examined the relationships between self-rated disability in persons with MD and both self-rated and objectively-measured cognitive functioning.

MethodsTwenty-one persons with MD and 21 control participants underwent neuropsychological assessment and z-scores representing deviations from control performance were calculated and averaged across the domains of psychomotor speed, initial learning, memory retention and executive function. Self-ratings of cognitive deficits SRCDs were reported on a 6-point scale for overall rating of cognitive change, speed of thinking, concentration, and short-term memory. Disability scores for self-rated physical, mental-health and functional ie. days out of role disability were computed from the Brief-Disability Questionnaire and the SF-12 -mental component- subscale.

ResultsPersons with MD had a mean age of 53.9 years SD = 11.0, 76% female and had moderate to high depression severity mean HDRS 21.7, sd = 4.4. As expected, depression severity was a strong predictor of physical r = 0.7, p < 0.01, mental-health r = 0.7, p < 0.01 and functional r = 0.8, p < 0.001 disability on the Brief Disability Questionnaire. Additionally, for physical disability, both overall SRCDs and objectively-measured psychomotor speed continued to be independent significant predictors after controlling for depression severity, uniquely accounting for 13% and 16% of variance respectively. For functional disability scores, objectively-measured memory impairment and overall SRCDs were no longer significant predictors after controlling for depression severity.

ConclusionWhile depression severity is associated with disability, the contributions of both self-rated and objectively-measured cognitive deficits are substantial and contribute uniquely and differentially to various forms of disability. Efforts directed at reducing cognitive deficits in depression may have the potential to reduce disability.

AbbreviationsMDmajor depression

MMSEMini-Mental State Examination

SRCDsself-reported cognitive deficits

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Author: Sharon L Naismith - Wendy A Longley - Elizabeth M Scott - Ian B Hickie

Source: https://link.springer.com/



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