A controlled trial of the Litebook light-emitting diode LED light therapy device for treatment of Seasonal Affective Disorder SADReport as inadecuate




A controlled trial of the Litebook light-emitting diode LED light therapy device for treatment of Seasonal Affective Disorder SAD - Download this document for free, or read online. Document in PDF available to download.

BMC Psychiatry

, 7:38

First Online: 07 August 2007Received: 10 April 2007Accepted: 07 August 2007

Abstract

BackgroundRecent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes LEDs whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder SAD.

MethodsThe efficacy of a LED light therapy device in the treatment of SAD was tested in a randomized, double-blind, placebo-controlled, multi-center trial. Participants aged 18 to 65 with SAD DSM-IV major depression with seasonal pattern were seen at Baseline and Randomization visits separated by 1 week, and after 1, 2, 3 and 4 weeks of treatment. Hamilton Depression Rating Scale scores SIGH-SAD were obtained at each visit. Participants with SIGH-SAD of 20 or greater at Baseline and Randomization visits were randomized to active or control treatment: exposure to the Litebook LED treatment device The Litebook Company Ltd., Alberta, Canada which delivers 1,350 lux white light with spectral emission peaks at 464 nm and 564 nm at a distance of 20 inches or to an inactivated negative ion generator at a distance of 20 inches, for 30 minutes a day upon awakening and prior to 8 A.M.

ResultsOf the 26 participants randomized, 23 completed the trial. Mean group SIGH-SAD scores did not differ significantly at randomization. At trial end, the proportions of participants in remission SIGH-SAD less than 9 were significantly greater Fisher-s exact test, and SIGH-SAD scores, as percent individual score at randomization, were significantly lower t-test, with active treatment than with control, both in an intent-to-treat analysis and an observed cases analysis. A longitudinal repeated measures ANOVA analysis of SIGH-SAD scores also indicated a significant interaction of time and treatment, showing superiority of the Litebook over the placebo condition.

ConclusionThe results of this pilot study support the hypothesis that light therapy with the Litebook is an effective treatment for SAD.

Trial registrationClinicaltrials.gov: NCT00139997

Electronic supplementary materialThe online version of this article doi:10.1186-1471-244X-7-38 contains supplementary material, which is available to authorized users.

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Author: Paul H Desan - Andrea J Weinstein - Erin E Michalak - Edwin M Tam - Ybe Meesters - Martine J Ruiter - Edward Horn - Jo

Source: https://link.springer.com/



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