Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety levelReport as inadecuate




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Annals of General Psychiatry

, 6:21

First Online: 10 August 2007Received: 11 January 2007Accepted: 10 August 2007

Abstract

BackgroundAnxiety levels in rats are correlated with interleukin-2 IL-2 levels in the brain. The aim of the present study was to investigate the effects of dioscorea wild yam, a Chinese medicine, on emotional behavior and IL-2 levels in the brain of ovariectomized OVX rats.

MethodsOne month after ovariectomy, female Wistar rats were screened in the elevated plus-maze EPM test to measure anxiety levels and divided into low anxiety LA and high anxiety HA groups, which were then given dioscorea 250, 750, or 1500 mg-kg-day by oral gavage for 27 days and were tested in the EPM on day 23 of administration and in the forced swim test FST on days 24 and 25, then 3 days later, the brain was removed and IL-2 levels measured.

ResultsCompared to sham-operated rats, anxiety behavior in the EPM was increased in half of the OVX rats. After chronic dioscorea treatment, a decrease in anxiety and IL-2 levels was observed in the HA OVX rats. Despair behavior in the FST was inhibited by the highest dosage of dioscorea.

ConclusionThese results show that OVX-induced anxiety and changes in neuroimmunological function in the cortex are reversed by dioscorea treatment. Furthermore, individual differences need to be taken into account when psychoneuroimmunological issues are measured and the EPM is a useful tool for determining anxiety levels when examining anxiety-related issues.

Electronic supplementary materialThe online version of this article doi:10.1186-1744-859X-6-21 contains supplementary material, which is available to authorized users.

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Author: Ying-Jui Ho - Ching-Fu Wang - Wen-Yu Hsu - Ting Tseng - Cheng-Chin Hsu - Mei-Ding Kao - Yuan-Feen Tsai

Source: https://link.springer.com/







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