Use of Aldosterone Antagonist to Treat Diarrhea and Hypokalemia of Ogilvie’s SyndromeReport as inadecuate




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Case Reports in Gastrointestinal Medicine - Volume 2016 2016, Article ID 1207240, 3 pages -

Case ReportEinstein Medical Center, Philadelphia, PA, USA

Received 3 September 2016; Accepted 27 September 2016

Academic Editor: Olga I. Giouleme

Copyright © 2016 Pradhum Ram et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ogilvie’s syndrome OS is a functional obstruction of the bowel due to an autonomic imbalance.
It often presents with diarrhea and is associated with hypokalemia.
We present a case of a 70-year-old male who developed severe abdominal distension, watery diarrhea, and persistent hypokalemia status after left hip arthroplasty after suffering from a femoral neck fracture due to a fall and was diagnosed with OS.
The persistent hypokalemia was slow to improve despite aggressive repletion because of the high potassium losses in the stool.
This is most likely mediated through the increased expression of BK channels in the colonic mucosa.
Aldosterone is theorized to have a role in the regulation of BK channels.
Spironolactone was subsequently given and resulted in marked improvement of the diarrhea and hypokalemia.
Thus, this case suggests a novel therapeutic approach for the treatment of Ogilvie’s syndrome-associated diarrhea and hypokalemia.





Author: Pradhum Ram, Abhinav Goyal, Marvin Lu, Joshua Sloan, and William McElhaugh

Source: https://www.hindawi.com/



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