Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in MiceReport as inadecuate




Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice - Download this document for free, or read online. Document in PDF available to download.

Evidence-Based Complementary and Alternative MedicineVolume 2011 2011, Article ID 532180, 11 pages

Research Article

Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan

Health Bioscience Team, Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan

Department of Internal Medicine, Graduate school of Medicine, Kobe University, Kobe 650-0017, Japan

Received 7 June 2010; Accepted 28 August 2010

Copyright © 2011 Go Bouike et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To clarify the mechanism of the antiallergic activity of Agaricus blazei Murill extract ABME, the present paper used an in vivo allergy model and an in vitro intestinal gut model. During OVA sensitization, the serum IgE levels decreased significantly in ABME group. Interleukin IL-4 and -5 produced from OVA-restimulated splenocytes was significantly decreased, and anti-CD3 -CD28 antibody treatment also reduced IL-10 -4, and -5 production and increased IFN- production in ABME group. These results suggest that oral administration of ABME improves Th1-Th2 balance. Moreover, a coculture system constructed of Caco-2 cells and splenocytes from OT-II mice or RAW 264.7 cells indicated that the significant increases in IFN- production by ABME treatment. Therefore, it was concluded that the antiallergic activity of ABME was due to the activation of macrophages by epithelial cells and the promotion of the differentiation of naïve T cells into Th1 cells in the immune.





Author: Go Bouike, Yosuke Nishitani, Hideyuki Shiomi, Masaru Yoshida, Takeshi Azuma, Takashi Hashimoto, Kazuki Kanazawa, and Masash

Source: https://www.hindawi.com/



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