Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar DisorderReport as inadecuate




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Neural Plasticity - Volume 2015 2015, Article ID 324825, 7 pages -

Research Article

Pediatric Bipolar Disorder Outpatient Program ProCAB, Universidade Federal do Rio Grande do Sul UFRGS, 90035-903 Porto Alegre, RS, Brazil

Hospital de Clínicas de Porto Alegre, Division of Medical Physics and Radiation Protection, 90035-903 Porto Alegre, RS, Brazil

Bipolar Disorder Unit, Molecular Psychiatry Unit and National Institute for Translational Medicine, CNPq., 90035-903 Porto Alegre, RS, Brazil

Federal University, UFRGS, 90035-903 Porto Alegre, RS, Brazil

UTHealth, Houston, TX 77030, USA

ADHD Outpatient Program PRODAH, UFRGS, 90035-903 Porto Alegre, RS, Brazil

National Science and Technology Institute for Children and Adolescents, 05403-010 São Paulo, SP, Brazil

University of Texas Health Science Center, Houston, TX 77030, USA

Received 18 August 2014; Revised 6 November 2014; Accepted 27 December 2014

Academic Editor: Benício N. Frey

Copyright © 2015 Tatiana Lauxen Peruzzolo et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pediatric bipolar disorder PBD is a serious mental disorder that affects the development and emotional growth of affected patients.
The brain derived neurotrophic factor BDNF is recognized as one of the possible markers of the framework and its evolution.
Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB.
Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF.
Subjects included 30 patients aged seven to seventeen years from the ProCAB Program for Children and Adolescents with Bipolar Disorder.
We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm

, respectively.
No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found.
We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescents.
Besides studies with larger sample sizes to confirm the present findings and longitudinal assessments, addressing brain development versus a control group and including drug-naive patients in different mood states may help clarify the role of BDNF in the brain changes consequent upon BD.





Author: Tatiana Lauxen Peruzzolo, Mauricio Anes, Andre de Moura Kohmann, Ana Claudia Mércio Loredo Souza, Ramiro Borges Rodrigues, J

Source: https://www.hindawi.com/



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