DISCO: A New Algorithm for Detecting 3D Protein Structure SimilarityReport as inadecuate




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1 Aristotle University of Thessaloniki

Abstract : Protein structure similarity is one of the most important aims pursued by bioinformatics and structural biology, nowadays.
Although quite a few similarity methods have been proposed lately, yet fresh algorithms that fulfill new preconditions are needed to serve this purpose.
In this paper, we provide a new similarity measure for 3D protein structures that detects not only similar structures but also similar substructures to a query protein, supporting both multiple and pairwise comparison procedures and combining many comparison characteristics.
In order to handle similarity queries we utilize efficient and effective indexing techniques such as M-trees and we provide interesting results using real, previously tested protein data sets.


Keywords : protein structure similarity indexing technique





Author: Nantia Iakovidou - Eleftherios Tiakas - Konstantinos Tsichlas -

Source: https://hal.archives-ouvertes.fr/



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