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Annals of General Psychiatry

, 15:36

First Online: 16 December 2016Received: 26 June 2016Accepted: 02 December 2016

Abstract

BackgroundThere have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between altered lipid profile and suicidal behavior in schizophrenic Tunisian patients.

MethodsAssay of total cholesterol TC, high-density lipoprotein cholesterol HDL-c, low-density lipoprotein cholesterol LDL-c, and triglycerides TG has been done for 126 schizophrenic patients with and without suicide attempts and 131 healthy controls recruited in the University Hospital of Monastir.

ResultsTC and LDL-c levels were significantly higher in schizophrenic patients compared to controls. TC was significantly lower in schizophrenic patients with suicide attempt compared to those without suicide attempt. Depending to the sonority of suicide attempt, TC was significantly lower in patients with recent suicide attempt compared to those with lifetime suicide attempt and without suicide attempt p < 0.001, and no significant differences between TG, LDL-c, and HDL-c were noted.

ConclusionsResults of this study showed that TC levels in schizophrenic patients after a recent suicide attempt are significantly lower than in patients without suicide attempt and with lifetime suicide attempts. TC can be one of biological markers defined suicidal risk for schizophrenic patients.

KeywordsLipids Cholesterol Schizophrenia Suicide AbbreviationsHDL-chigh-density lipoprotein cholesterol

LDL-clow-density lipoprotein cholesterol

TCtotal cholesterol

TGtriglycerides

SAsuicide attempt

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