Brain structure differences among male schizophrenic patients with history of serious violent acts: an MRI voxel-based morphometric studyReport as inadecuate




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BMC Psychiatry

, 17:105

Forensic psychiatry

Abstract

BackgroundThe biological underpinnings of serious violent behaviors in patients with schizophrenia remain unclear. The aim of this study was to identify the characteristics of brain morphometry in patients with schizophrenia and a history of serious violent acts, who were being treated under relatively new legislation for offenders with mental illness in Japan where their relevant action should be strongly associated with their mental illness. We also investigated whether morphometric changes would depend on types of serious violent actions or not.

MethodsThirty-four male patients with schizophrenia who were hospitalized after committing serious violent acts were compared with 23 male outpatients or inpatients with schizophrenia and no history of violent acts. T1-weighted magnetic resonance imaging MRI with voxel-based morphometry was used to assess gray matter volume. Additionally, patients with violent acts were divided based on whether their relevant actions were premeditated or not. The regional volumes of these two groups were compared to those of the control patient group.

ResultsPatients with schizophrenia and a history of serious violent acts showed significantly smaller regional volumes of the right inferior temporal area expanded to the middle temporal gyrus and the temporal pole, and the right insular area compared to patients without a history of violence. Patients with premeditated violent acts showed significantly smaller regional volumes of the right inferior temporal area, the right insular area, the left planum polare area including the insula, and the bilateral precuneus area including the posterior cingulate gyrus than those without a history of violence, whereas patients with impulsive violent acts showed significantly smaller volumes of only the right inferior temporal area compared to those without a history of violence.

ConclusionsPatients with schizophrenia and a history of serious violent acts showed structural differences in some brain regions compared to those with schizophrenia and no history of violence. Abnormalities in the right inferior temporal area were relatively common but did not depend on whether the violent actions were premeditated or not, and abnormalities in a wider range may be attributed to not only planning the violent action against others but also to maintaining that plan.

Trial registrationUMIN.ac.jp UMIN000008065. Registered 2012-05-31.

KeywordsSchizophrenia MRI voxel-based morphometry Violent acts Premeditation AbbreviationsGMVGray matter volume

ICVIntracranial volume

MTSAThe Medical Treatment and Supervision Act, also known as the Act on Medical Care and Treatment for Persons Who Have Caused Serious Cases Under the Condition of Insanity

This article has been updated to change the order of Fig.s’ 2 and 3. The present order is correct.

An erratum to this article is available at http:-dx.doi.org-10.1186-s12888-017-1302-6.

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Author: Noriomi Kuroki - Hiroko Kashiwagi - Miho Ota - Masanori Ishikawa - Hiroshi Kunugi - Noriko Sato - Naotsugu Hirabayashi - To

Source: https://link.springer.com/



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