Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat DietReport as inadecuate




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BioMed Research International - Volume 2015 2015, Article ID 249741, 7 pages -

Research ArticleDepartment of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received 1 December 2014; Revised 22 January 2015; Accepted 22 January 2015

Academic Editor: Carlos Dieguez

Copyright © 2015 Hua Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We aimed to examine whether proinflammatory cytokines participated in prostate cancer PCa development and progression promoted by high-fat diet HFD. Methods. TRAMP transgenic adenocarcinoma mouse prostate mice were randomly divided into two groups: normal diet group and HFD group. Mortality rate and tumor formation rate were examined. TRAMP mice were sacrificed and sampled on the 20th, 24th, and 28th week, respectively. Levels of proinflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, were tested by FlowCytomix. Prostate tissue of TRAMP mice was used for histology study. Results. A total of 13 deaths of TRAMP mice were observed, among which 3 8.33% were from the normal diet group and 10 27.78% from the HFD group. The mortality rate of TRAMP mice from HFD group was significantly higher than that of normal diet group . Tumor formation rate at 20th week of age of HFD group was significantly higher than that of normal diet group . Proinflammatory cytokines levels, including IL-1α, IL-1β, IL-6, and TNF-α, were significantly higher in HFD TRAMP mice. Conclusions. HFD could promote TRAMP mouse PCa development and progression with elevated proinflammatory cytokines levels. Proinflammatory cytokines could contribute to PCa development and progression promoted by HFD.





Author: Hua Xu, Meng-bo Hu, Pei-de Bai, Wen-hui Zhu, Sheng-hua Liu, Jun-yao Hou, Zu-quan Xiong, Qiang Ding, and Hao-wen Jiang

Source: https://www.hindawi.com/



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