Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance ChondrogenesisReport as inadecuate




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BioMed Research InternationalVolume 2014 2014, Article ID 369528, 10 pages

Review Article

School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia

Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2795, Australia

Received 19 February 2014; Accepted 27 March 2014; Published 19 May 2014

Academic Editor: Jiing-Kuan Yee

Copyright © 2014 Saliya Gurusinghe and Padraig Strappe. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Current cell based treatment for articular cartilage and osteochondral defects are hampered by issues such as cellular dedifferentiation and hypertrophy of the resident or transplanted cells. The reduced expression of chondrogenic signalling molecules and transcription factors is a major contributing factor to changes in cell phenotype. Gene modification of chondrocytes may be one approach to redirect cells to their primary phenotype and recent advances in nonviral and viral gene delivery technologies have enabled the expression of these lost factors at high efficiency and specificity to regain chondrocyte function. This review focuses on the various candidate genes that encode signalling molecules and transcription factors that are specific for the enhancement of the chondrogenic phenotype and also how epigenetic regulators of chondrogenesis in the form of microRNA may also play an important role.





Author: Saliya Gurusinghe and Padraig Strappe

Source: https://www.hindawi.com/



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