Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisReport as inadecuate




Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Journal of Diabetes Research - Volume 2016 2016, Article ID 3694957, 19 pages -

Research Article

Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China

Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China

Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong

Department of Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, China

Received 21 March 2016; Revised 9 August 2016; Accepted 30 August 2016

Academic Editor: Bernard Portha

Copyright © 2016 Yong-chao Qiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of this study was to investigate the changes of regulatory T cells Treg, interleukin-6 IL-6, IL-10, transforming growth factor-β TGF-β, and tumor necrosis factor-alpha TNF-α in patients with type 2 diabetes mellitus T2DM. Methods. We performed a comprehensive search up to July 2016 for all clinical studies about the changes of Treg, IL-6, IL-10, IL-17, TGF-β, and TNF-α in T2DM patients versus healthy controls. Results. A total of 91 articles 5642 cases and 7378 controls were included for this meta-analysis. Compared with the controls all , the patients had increased serum levels of IL-6, TGF-β, and TNF-α but decreased the percentage of peripheral CD4

CD25

Foxp3

Treg and serum IL-10 level. Furthermore, the percentage of peripheral CD4

CD25

Foxp3

Treg and serum IL-10 level were significantly lower in the patients with complication and in the patients without complication, respectively. No significant changes about the percentage of CD4

CD25

Treg and serum IL-17 level were found in T2DM patients. Conclusions. T2DM patients have decreased the percentage of peripheral CD4

CD25

Foxp3

Treg and levels of serum IL-10 but elevated serum levels of IL-6, TGF-β, and TNF-α. Presence of diabetic complications further lowers the peripheral CD4

CD25

Foxp3

Treg number.





Author: Yong-chao Qiao, Jian Shen, Lan He, Xue-zhi Hong, Fang Tian, Yan-hong Pan, Ling Liang, Xiao-xi Zhang, and Hai-lu Zhao

Source: https://www.hindawi.com/



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