Biocompatibility of subretinal parylene-based Ti-Pt microelectrode array in rabbit for further artificial vision studiesReport as inadecuate




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Journal of Ocular Biology, Diseases, and Informatics

, Volume 2, Issue 1, pp 33–36

First Online: 27 March 2009Received: 06 December 2008Accepted: 16 February 2009

Abstract

To evaluate the biocompatibility of subretinal implanted parylene-based Ti-Pt microelectrode arrays MEA.
Eyes were enucleated 3 months after MEAs were implanted into the subretinal space of rabbits.
Morphological changes of the retinas were investigated by HandE staining.
Immunohistochemical staining for glial fibrillary acidic protein and opsin were performed to evaluate changes in Muller cells and photoreceptors in the retinas.
Retina tissue around the array remained intact.
Photoreceptor degeneration and glial cell activation were observed in the retina overlaying the MEA implant.
However, the cells in the inner retinal layers were preserved.
Photoreceptor degeneration and glial cell activation at the MEA–retina interface are expected to be a normal reaction to implantation.
Material used in this experiment has good biocompatibility within the subretinal environment and is expected to be promising in the further retinal prosthesis studies.

KeywordsSubretinal electrode array Biocompatibility  Download fulltext PDF



Author: Weihong Yu - Xuqian Wang - Chan Zhao - Zhikun Yang - Rongping Dai - Fangtian Dong

Source: https://link.springer.com/



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