Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource SettingsReport as inadecuate




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AIDS Research and TreatmentVolume 2011 2011, Article ID 463704, 11 pages

Review Article

Medical Research Council UK Laboratories, Atlantic Road, P.O. Box 273, Fajara, Gambia

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK

MRC-UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, UK

Received 27 May 2010; Accepted 12 December 2010

Academic Editor: Ann Duerr

Copyright © 2011 Kevin Peterson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

HIV-2 contributes approximately a third to the prevalence of HIV in West Africa and is present in significant amounts in several low-income countries outside of West Africa with historical ties to Portugal. It complicates HIV diagnosis, requiring more expensive and technically demanding testing algorithms. Natural polymorphisms and patterns in the development of resistance to antiretrovirals are reviewed, along with their implications for antiretroviral therapy. Nonnucleoside reverse transcriptase inhibitors, crucial in standard first-line regimens for HIV-1 in many low-income settings, have no effect on HIV-2. Nucleoside analogues alone are not sufficiently potent enough to achieve durable virologic control. Some protease inhibitors, in particular those without ritonavir boosting, are not sufficiently effective against HIV-2. Following review of the available evidence and taking the structure and challenges of antiretroviral care in West Africa into consideration, the authors make recommendations and highlight the needs of special populations.





Author: Kevin Peterson, Sabelle Jallow, Sarah L. Rowland-Jones, and Thushan I. de Silva

Source: https://www.hindawi.com/



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