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BMC Neurology

, 11:146

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Abstract

BackgroundThere is a growing interest in the role of the endothelium in migraine. Recently, our group showed differences in endothelial function between the anterior and posterior cerebral circulation in healthy subjects, reduced vasodilatatory capacity of the posterior cerebral circulation and unimpaired systemic endothelial function in migraine patients without comorbidities. However, the relationship between cerebral and systemic endothelial function and the anterior and posterior cerebral endothelial function in migraine patients is still not clear.

MethodsWe compared cerebral and systemic endothelial function through post-hoc linear regression analysis of cerebrovascular reactivity CVR to L-arginine between the middle cerebral artery MCA and flow-mediated vasodilatation FMD of the right brachial artery and the posterior cerebral artery PCA and FMD in migraine patients without comorbidities and in healthy subjects. The anterior and posterior cerebral endothelial function was also compared using post-hoc linear regression analysis between CVR to L-arginine in the MCA and the PCA.

ResultsNo significant correlation was found between CVR to L-arginine in the MCA and FMD and in the PCA and FMD in migraine patients with aura p = 0.880 vs. p = 0.682, without aura p = 0.153 vs. p = 0.179 and in healthy subjects p = 0.869 vs. p = 0.662. On the other hand, we found a significant correlation between CVR to L-arginine in the MCA and PCA in migraine patients with aura p = 0.004, without aura p = 0.001 and in healthy subjects p = 0.002. Detailed analysis of the linear regression between all migraine patients and healthy subjects did not show any difference in the regression coefficient slope p = 0.382. However, a significant difference in curve elevation intercept was found p = 0.002.

ConclusionsOur study suggests that the endothelial function in the cerebral and systemic circulation might be different in migraine patients without comorbidities, while that of the anterior and posterior cerebral circulation might be coupled. These results could improve understanding of endothelial function in migraine patients without comorbidities.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-11-146 contains supplementary material, which is available to authorized users.

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Author: Denis Perko - Janja Pretnar-Oblak - Mišo Šabovič - Marjan Zaletel - Bojana Žvan

Source: https://link.springer.com/



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