Evaluation of an electronic diary for improvement of adherence to interferon beta-1b in patients with multiple sclerosis: design and baseline results of an observational cohort studyReport as inadecuate




Evaluation of an electronic diary for improvement of adherence to interferon beta-1b in patients with multiple sclerosis: design and baseline results of an observational cohort study - Download this document for free, or read online. Document in PDF available to download.

BMC Neurology

, 13:117

Demyelinating diseases

Abstract

BackgroundMultiple sclerosis is a chronic, incurable, demyelinating disease that requires long-term treatment. Rates of non-adherence to prescribed therapy of up to 50% have been reported for chronic diseases. Strategies to improve treatment adherence are therefore of the utmost importance. This study will evaluate the effect of using electronic and paper diaries on treatment adherence to interferon beta-1b in patients with a first clinical isolated syndrome CIS or relapsing-remitting multiple sclerosis RRMS. Here we report on the study design and results of baseline assessments.

MethodsPatients were recruited into a prospective national multicenter cohort study for an observational period of 2 years. At the start of the study, patients opted to use a digital DiD or paper diary PD to document self-administered injections of interferon beta-1b. Adherence to treatment will be assessed on the dropout rate at the end of the observation period and on the regularity of injections every other day at 6-month intervals. Patient-related health outcomes will also be evaluated.

Results700 patients with a mean age of 38.3 SD 10.3 years and a mean duration of disease since diagnosis of 3.6 SD 5.9 years were enrolled. 383 patients opted for the digital diary, 192 of which included an injection reminder. Significantly more male than female patients opted for the DiD. Only gender was identified as a factor influencing the decision for DiD or PD. Based on rating scales, a significantly higher proportion of women had depressive comorbidities at baseline.

ConclusionsDemographic characteristics of the two cohorts were similar at baseline. More women chose a paper diary, and more had depression at baseline. These imbalances will be addressed in the analysis of the study as possible confounders influencing long-term treatment adherence in the digital and paper diary cohorts.

Trial RegistrationClinicalTrials.gov Identifier: NCT00902135.

KeywordsAdherence Interferon beta-1b Non-interventional study Electronic diary Multiple sclerosis Immunomodulation Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-13-117 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Uwe K Zettl - Ulrike Bauer-Steinhusen - Thomas Glaser - Klaus Hechenbichler - Volker Limmroth - for the Study Group

Source: https://link.springer.com/







Related documents