Long-Term Outcome of Patients with Complete Pathologic Response after Neoadjuvant Chemoradiation for cT3 Rectal Cancer: Implications for Local Excision Surgical StrategiesReport as inadecuate




Long-Term Outcome of Patients with Complete Pathologic Response after Neoadjuvant Chemoradiation for cT3 Rectal Cancer: Implications for Local Excision Surgical Strategies - Download this document for free, or read online. Document in PDF available to download.

Annals of Surgical Oncology

, Volume 18, Issue 13, pp 3686–3693

First Online: 21 June 2011Received: 19 March 2011

Abstract

BackgroundNeoadjuvant chemoradiotherapy CRT followed by radical surgery including total mesorectal excision TME is standard treatment in patients with locally advanced rectal cancer. Emerging data indicate that patients with complete pathologic response ypCR after CRT have favorable outcome, suggesting the possibility of less invasive surgical treatment. We analyzed long-term outcome of cT3 rectal cancer treated by neoadjuvant CRT in relation to ypCR and type of surgery.

MethodsThe study population comprised 139 patients 93 men, 46 women; median age 62 years with cT3N0–1M0 mid and distal rectal adenocarcinoma treated by CRT and surgery 110 TME and 29 local excision at our institution between 1996 and 2008. At pathology, ypCR was defined as no residual cancer cells in the primary tumor.

ResultsTumors of 42 patients 30.2% were classified as ypCR. After a median follow-up of 55.4 months, comparing patients with ypCR to patients with no ypCR, 5-year disease-specific survival was 95.8% versus 78.0% P = 0.004, and 5-year disease-free survival was 90.1% vs. 64.0% P = 0.004. In patients with ypCR, no statistically significant outcome difference was observed between TME and local excision. In patients treated by local excision, comparing patients with ypCR to patients with no ypCR, 5-year disease-free survival was 100% vs. 65.5% P = 0.024, and 5-year local recurrence-free survival was 92.9% vs. 66.7% P = 0.047.

ConclusionsWith retrospective analysis limitations, our data confirm favorable long-term outcome of cT3 rectal cancer with ypCR after CRT and warrant clinical trials exploring local excision surgical strategies.

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Source: https://link.springer.com/article/10.1245/s10434-011-1822-0







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