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Journal of Neural Transmission

, Volume 121, Issue 9, pp 1145–1155

First Online: 21 May 2014Received: 24 December 2013Accepted: 03 May 2014

Abstract

Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders ASD and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task go-no-go paradigm. Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability.

KeywordsASD Functional connectivity ICA Cognitive control Rigid behavior S. Ambrosino and D. J. Bos contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1007-s00702-014-1237-8 contains supplementary material, which is available to authorized users.

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Author: S. Ambrosino - D. J. Bos - T. R. van Raalten - N. A. Kobussen - J. van Belle - B. Oranje - S. Durston

Source: https://link.springer.com/







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