Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy SpecimensReport as inadecuate




Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens - Download this document for free, or read online. Document in PDF available to download.

Pathology Research InternationalVolume 2014 2014, Article ID 262195, 8 pages

Research Article

Department of Urology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia

Medico Polyclinic, Agatićeva 8, 51000 Rijeka, Croatia

Department of Oncology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia

Department of Pathology, School of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia

Received 15 February 2014; Accepted 5 June 2014; Published 6 July 2014

Academic Editor: Shahid Pervez

Copyright © 2014 Romano Oguić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to evaluate the expression of matrix metalloproteinase 2 MMP-2 and matrix metalloproteinase 9 MMP-9 in prostate cancer in the main tumor mass and tumor cells at the positive margin as well as the influence of these biomarkers on the biochemical recurrence of the disease in prostatectomy patients. Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters. Tumors with positive surgical margins showed significantly higher overall expression of MMP-9 versus tumors with negative resection margins . MMP-9 expression was significantly elevated in tumors from patients who had biochemical recurrence . In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence . Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence odds ratio = 10.29; . Expression of MMP-2 in tumor cells was significantly higher at the positive margins than in the main tumor mass . The present results highlight the potential value of MMP-2 and MMP-9 expression for predicting the behavior of prostate tumors after prostatectomy with both positive and negative surgical margins.





Author: Romano Oguić, Vladimir Mozetič, Eleonora Cini Tešar, Dora Fučkar Čupić, Elvira Mustać, and Gordana Đorđević

Source: https://www.hindawi.com/



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