Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug DeliveryReport as inadecuate




Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug Delivery - Download this document for free, or read online. Document in PDF available to download.

Journal of Pharmaceutics - Volume 2014 2014, Article ID 262194, 13 pages -

Research Article

National Institute of Pharmaceutical Education and Research NIPER, B. V. Patel Pharmaceutical Education and Research Development PERD, S G Highway, Thaltej, Ahmedabad 380054, India

Department of Pharmaceutics, Maliba Pharmacy College, Uka Tarsadia University, Bardoli-Mahuva Road, Surat District, Gopalvidyanagar 380054, India

Received 19 November 2013; Revised 17 February 2014; Accepted 19 February 2014; Published 10 April 2014

Academic Editor: Nayanabhirama Udupa

Copyright © 2014 Himanshu Bhatt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of the research was to present Budesonide BUD as a novel formulation showing improved aqueous solubility, which may decrease variability in and found in inflammatory bowel disease IBD patients, and drug targeting to colon. To improve aqueous solubility, solid dispersion SD of the BUD with poloxamer 188 was prepared by melting method. Physical characterization of solid dispersion was performed. The SD was used to prepare tablet equivalent to 9 mg of BUD. The tablet was coated with enteric polymers Eudragit S100 and Eudragit L100 to target colon. The ratio of polymers and percentage coating was optimized using statistical design. Variables studied in design were ratio of enteric polymers and the effect of percentage coating on in vitro drug release. Dissolution at different pH showed that drug release in colon could be modified by optimizing the ratio of polymers and percentage coating. The dissolution data showed that the percentage coating and ratio of polymers are very important to get lag time and optimum formulation. The optimized batch from statistical design was kept under accelerated condition for three months. After accelerated stability study, there was no significant change in the drug release.





Author: Himanshu Bhatt, Bhargavi Naik, and Abhay Dharamsi

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents