Argon prevents the development of locomotor sensitization to amphetamine and amphetamine-induced changes in mu opioid receptor in the nucleus accumbensReport as inadecuate




Argon prevents the development of locomotor sensitization to amphetamine and amphetamine-induced changes in mu opioid receptor in the nucleus accumbens - Download this document for free, or read online. Document in PDF available to download.

Medical Gas Research

, 4:21

Inert gases

Abstract

Systemic administration of γ-amino-butyric acid type A GABA-A and benzodiazepine receptor agonists has been reported to block the development of locomotor sensitization to amphetamine. Here, we investigated whether the non-anesthetic noble gas argon, shown to possess agonistic properties at these receptors, may block the acquisition of amphetamine-induced locomotor sensitization and mu opioid receptor activation in the nucleus accumbens. Rats were pretreated with saline solution or amphetamine 1 mg-kg from day 1 to day 3 and then exposed, immediately after injection of amphetamine, to medicinal air or argon at 75 vol% with the remainder being oxygen. After a 3-day period of withdrawal, rats were challenged with amphetamine on day 7. Rats pretreated with amphetamine and argon had lower locomotor activity U = 5, P < 0.005 and mu opioid receptor activity in the nucleus accumbens U = 0, P < 0.001 than rats pretreated with amphetamine and air. In contrast, argon had effect on locomotor and mu receptor activity neither in rats pretreated with saline and challenged with amphetamine acute amphetamine nor in rats pretreated and challenged with saline solution controls. These results indicate that argon inhibits the development of both locomotor sensitization and mu opioid receptor activation induced by repeated administration of amphetamine.

KeywordsAmphetamine Locomotor sensitization GABA Benzodiazepine Argon Noble gases Electronic supplementary materialThe online version of this article doi:10.1186-s13618-014-0021-z contains supplementary material, which is available to authorized users.

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