Influence of morphology and hemodynamic factors on rupture of multiple intracranial aneurysms: matched-pairs of ruptured-unruptured aneurysms located unilaterally on the anterior circulationReport as inadecuate




Influence of morphology and hemodynamic factors on rupture of multiple intracranial aneurysms: matched-pairs of ruptured-unruptured aneurysms located unilaterally on the anterior circulation - Download this document for free, or read online. Document in PDF available to download.

BMC Neurology

, 14:253

Neurocritical care

Abstract

BackgroundThe authors evaluated the impact of morphological and hemodynamic factors on the rupture of matched-pairs of ruptured-unruptured intracranial aneurysms on one patient’s ipsilateral anterior circulation with 3D reconstruction model and computational fluid dynamic method simulation.

Methods20 patients with intracranial aneurysms pairs on the same-side of anterior circulation but with different rupture status were retrospectively collected. Each pair was divided into ruptured-unruptured group. Patient-specific models based on their 3D-DSA images were constructed and analyzed. The relative locations, morphologic and hemodynamic factors of these two groups were compared.

ResultsThere was no significant difference in the relative bleeding location. The morphological factors analysis found that the ruptured aneurysms more often had irregular shape and had significantly higher maximum height and aspect ratio. The hemodynamic factors analysis found lower minimum wall shear stress WSSmin and more low-wall shear stress-area LSA in the ruptured aneurysms than that of the unruptured ones. The ruptured aneurysms more often had WSSmin on the dome.

ConclusionsIntracranial aneurysms pairs with different rupture status on unilateral side of anterior circulation may be a good disease model to investigate possible characteristics linked to rupture independent of patient characteristics. Irregular shape, larger size, higher aspect ratio, lower WSSmin and more LSA may indicate a higher risk for their rupture.

KeywordsIntracranial aneurysms Multiple aneurysm Anterior circulation Rupture Computational fluid dynamics AbbreviationsACAAnterior cerebral artery

ACoAAnterior communicating artery

ASAtherosclerosis

BHBrain hernia

CFDComputational fluid dynamics

CHDCoronary heart disease

CICerebral infarction

DMDiabetes mellitus

DVTDeep vein thrombosis

HBPHypertension

HHCYHyperhomocysteinemia

HPLHyperlipidemia

ICAInternal carotid artery

LSALow wall shear stress area

MCAMiddle cerebral artery

OSIOscillatory shear index

PKDPolycystic kidney disease

TAWSSTime averaged wall shear stress

WSSWall shear stress

WSSmaxThe maximum wall shear stress

WSSminThe minimum wall shear stress

Electronic supplementary materialThe online version of this article doi:10.1186-s12883-014-0253-5 contains supplementary material, which is available to authorized users.

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Author: Ying Zhang - Xinjian Yang - Yang Wang - Jian Liu - Chuanhui Li - Linkai Jing - Shengzhang Wang - Haiyun Li

Source: https://link.springer.com/







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