Heat exposure and bicycling trigger recurrent aseptic meningitis: a case reportReport as inadecuate




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BMC Neurology

, 14:230

Neurocritical care

Abstract

BackgroundAseptic meningitis associated with herpes simplex virus type 2 often has a relapsing-remitting clinical phenotype. Factors that lead to disease activation and reactivation are currently incompletely understood.

Case presentationWe describe the case of a 49-year-old Caucasian man who developed recurrent episodes of herpes simplex virus type 2-associated aseptic meningitis in the setting of heat exposure and bicycling. This case is compelling in that substantial data were available to the examining physicians on the amount of physical exercise and heat exposure. Strenuous physical activities or heat exposure in isolation did not cause re-occurrence of clinical signs and symptoms.

ConclusionsThis case illustrates that the dual activation of mechanical and temperature receptors in dorsal root ganglia may lead to the recurrent reactivation and afferent dissemination of latent herpes simplex virus type 2 in some patients.

AbbreviationsCSFCerebrospinal fluid

HSVHerpes simplex virus

MRIMagnetic resonance imaging

NKNatural killer

PCRPolymerase chain reaction

ThT helper cell

TLRToll-like receptor

WBCWhite blood cells

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Author: Olaf Stuve - Ellen Marder - Annette Okai - Mark Stettner - Bernd C Kieseier

Source: https://link.springer.com/







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