Clinical significance of multifocal and multicentric breast cancers and choice of surgical treatment: a retrospective study on a series of 1158 casesReport as inadecuate




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BMC Surgery

, 15:1

First Online: 14 January 2015Received: 03 February 2014Accepted: 07 January 2015

Abstract

BackgroundThe biological and clinical significance of multifocal and multicentric MF-MC breast cancers and the choice of appropriate surgical treatment for these tumors are still debated.

Methods1158 women operated on for a stage I-III breast cancer were included in this retrospective study; clinical and pathological data were obtained from the institutional database of the Department of Oncology of the University of Siena, Italy. The impact of MF-MC breast cancers on patterns of recurrence and breast cancer specific survival BCSS was investigated in relation to the type of surgical treatment.

ResultsMF and MC cancers were present in 131 cases 11.3% and 60 cases 5.2% respectively and were more frequently treated with mastectomy 55 MF and 60 MC cancers, 81.2% than with breast conserving surgery 36 MF cancers, 18.9%; p < 0.001. MF and MC breast cancers were associated with a worse prognosis with a BCSS of 154 months compared to 204 months of unicentric cancers p < 0.001. In multivariate analysis, MF-MC cancers were independent prognostic factors for BCSS together with higher number of metastatic axillary nodes, absence of estrogen receptors and high proliferative activity. MF and MC cancers were related to a significantly shorter BCSS in patients submitted to mastectomy as well as those submitted to breast conserving surgery. Relapse at any site was higher in the subgroup of MF and MC cancers but the incidence of loco-regional and distant recurrences did not differ between patients treated with mastectomy or breast conserving surgery.

ConclusionsOur results indicate that MF-MC cancers have a negative impact on prognosis and are related to higher loregional and distant relapse independently from the type of surgery performed. Adjuvant therapies did not modify the poorer outcome, but in patients receiving adjuvant anthacyclines, the differences with unicentric tumors were reduced. Our data support the hypothesis that MF-MC tumors may have a worse biological behavior and that the presence of multiple foci should be considered in planning adjuvant treatments.

KeywordsBreast cancer Multifocal breast cancer Multicentric breast cancer Breast cancer surgery Breast cancer prognosis AbbreviationsMF-MCMultifocal and multicentric

BCSSBreast cancer specific survival.

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Author: Alessandro Neri - Daniele Marrelli - Tiziana Megha - Francesca Bettarini - Damiana Tacchini - Lorenzo De Franco - Franco Ro

Source: https://link.springer.com/article/10.1186/1471-2482-15-1







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