An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamicsReport as inadecuate




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BMC Neurology

, 15:95

First Online: 23 June 2015Received: 24 February 2015Accepted: 10 June 2015

Abstract

BackgroundThe relationship between extracranial venous system abnormalities and central nervous system disorders has been recently theorized. In this paper we delve into this hypothesis by modeling the venous drainage in brain and spinal column areas and simulating the intracranial flow changes due to extracranial morphological stenoses.

MethodsA lumped parameter model of the cerebro-spinal venous drainage was created based on anatomical knowledge and vessels diameters and lengths taken from literature. Each vein was modeled as a hydraulic resistance, calculated through Poiseuille’s law. The inputs of the model were arterial flow rates of the intracranial, vertebral and lumbar districts. The effects of the obstruction of the main venous outflows were simulated. A database comprising 112 Multiple Sclerosis patients Male-Female = 42-70; median age ± standard deviation = 43.7 ± 10.5 years was retrospectively analyzed.

ResultsThe flow rate of the main veins estimated with the model was similar to the measures of 21 healthy controls Male-Female = 10-11; mean age ± standard deviation = 31 ± 11 years, obtained with a 1.5 T Magnetic Resonance scanner. The intracranial reflux topography predicted with the model in cases of internal jugular vein diameter reduction was similar to those observed in the patients with internal jugular vein obstacles.

ConclusionsThe proposed model can predict physiological and pathological behaviors with good fidelity. Despite the simplifications introduced in cerebrospinal venous circulation modeling, the key anatomical feature of the lumped parameter model allowed for a detailed analysis of the consequences of extracranial venous impairments on intracranial pressure and hemodynamics.

KeywordsBlood flow Blood pressure Cerebrovascular circulation Nervous system Veins Stefania Marcotti and Lara Marchetti contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1186-s12883-015-0352-y contains supplementary material, which is available to authorized users.

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Author: Stefania Marcotti - Lara Marchetti - Pietro Cecconi - Emiliano Votta - Gianfranco Beniamino Fiore - Antonello Barberio - St

Source: https://link.springer.com/



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