Combined endothelial and epithelial barrier disruption of the colon may be a contributing factor to the Ebola sepsis-like syndromeReport as inadecuate




Combined endothelial and epithelial barrier disruption of the colon may be a contributing factor to the Ebola sepsis-like syndrome - Download this document for free, or read online. Document in PDF available to download.

Patient Safety in Surgery

, 9:1

First Online: 23 January 2015Received: 12 December 2014Accepted: 16 December 2014

Abstract

After an initial febrile viral syndrome, infection with Ebola virus often induces an explosive late -Ebola sepsis-like syndrome- which appears very similar to some phenotypes of bacterial sepsis and is commonly fatal. It is possible that direct and diffuse viral infection of both the endothelium and epithelium of the colon may cause sufficient disruption of both the endothelial and epithelial barriers to induce exposure or leakage of endotoxin and bacterial antigens to, or into, the vascular system precipitating or exacerbating the Ebola sepsis-like syndrome. If colonic barrier disruption or vascular exposure of bacterial antigens from the colon is found to comprise an important mechanism of the Ebola sepsis-like syndrome, protocolized timed decontamination of the bowel with or without timed prophylactic antibiotics might warrant investigation.

KeywordsEbola Sepsis Translocation Bacteremia Endotoxin Decontamination Antibiotics Intestine Cytokines Colon AbbreviationsEBOVEbola virus

ESLSEbola sepsis-like syndrome

PCRPolymerase chain reaction

Electronic supplementary materialThe online version of this article doi:10.1186-s13037-014-0048-z contains supplementary material, which is available to authorized users.

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Author: Lawrence A Lynn

Source: https://link.springer.com/article/10.1186/s13037-014-0048-z







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