Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania L. amazonensis and Leishmania V. braziliensis Infection in Sapajus apella PrimateReport as inadecuate




Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania L. amazonensis and Leishmania V. braziliensis Infection in Sapajus apella Primate - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2014 2014, Article ID 134236, 8 pages -

Research Article

Infectious Diseases Laboratory LIM-50, Pathology Department, Medical School of São Paulo University, Avenida Dr. Arnaldo, 455-1° Andar, Sala 1209, 01246-903 São Paulo, SP, Brazil

Leishmaniasis Laboratory, Evandro Chagas Institute, Ministry of Health, Rodovia BR 316 s-n, 67030-000 Ananindeua, PA, Brazil

Tropical Medicine Nucleus, Pará Federal University, Avenida Generalíssimo Deodoro 92, 66055-240 Belém, PA, Brazil

Received 10 February 2014; Revised 21 June 2014; Accepted 13 August 2014; Published 28 August 2014

Academic Editor: Amogh A. Sahasrabuddhe

Copyright © 2014 Márcia Dalastra Laurenti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to characterize the immunopathological response in the skin of S. apella infected with Leishmania L. amazonensis and L. V. braziliensis parasites, the main causative agents of localized cutaneous leishmaniasis in South America. In infected animals, amastigote forms of L. L. amazonensis could be detected till 120 days postinfection PI, while, in L. V. braziliensis infection, parasites could be detected until 180 days PI in the skin sections. CD20

cells were detected throughout the experimental time in both groups as well as in CD3

cells, which appeared to be activated because high densities of inducible nitric oxide synthase iNOS

cells were detected at 60 and 90 days PI in both studied groups. After 60 and 120 days PI, decrease in iNOS

cells was observed in L. L. amazonensis and L. V. braziliensis, respectively, which was associated with parasite clearance. Increase in lysozyme

cells was observed during the experimental infections, which also can be associated with parasite killing.





Author: Márcia Dalastra Laurenti, Luiz Felipe Domingues Passero, Thaise Yumie Tomokane, Fernanda de Camargo Francesquini, Mussya Ciso

Source: https://www.hindawi.com/



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