Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis MAP antibodies in Sardinian multiple sclerosis patients: associated or independent risk factorsReport as inadecuate




Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis MAP antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors - Download this document for free, or read online. Document in PDF available to download.

BMC Neurology

, 16:148

Demyelinating diseases

Abstract

BackgroundAmongst Sardinians the human leukocyte antigen HLA DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis MS, while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis MAP are predisposing factors. We studied the correlation between MAP and HLA.

MethodsFive hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective.

ResultsAnti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without p = 0.04.

ConclusionsWe showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.

KeywordsMycobacterium avium subspecies paratuberculosis Multiple sclerosis HLA Sardinia AbbreviationsAbsAntibodies

EBVEpstein-barr virus

HCHealthy controls

HLAHuman leukocyte antigen

MSMultiple sclerosis

MAPMycobacterium avium subspecies paratubercolosis

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Author: J. Frau - D. Cossu - C. Sardu - G. Mameli - G. Coghe - L. Lorefice - G. Fenu - S. Tranquilli - L. A. Sechi - M. G. Mar

Source: https://link.springer.com/



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