Cardiovascular Risk Factors and Total Serum Antioxidant Capacity in Healthy Men and in Men with Coronary Heart DiseaseReport as inadecuate




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BioMed Research InternationalVolume 2014 2014, Article ID 216964, 8 pages

Research Article

Department of Geriatrics, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland

Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego Street 7-9, 90-752 Lodz, Poland

Department of Hygiene and Health Promotion, Medical University of Lodz, Jaracza Street 63, 90-251 Lodz, Poland

Cardiac Rehabilitation Centre, Copernicus Memorial Hospital, Lodz, Popioly Street 40, 93-438 Lodz, Poland

Department of Physical Medicine, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland

Department of Clinical Physiology, Medical University of Lodz, Mazowiecka Street 6-8, 92-215 Lodz, Poland

Department of Sports Medicine, Medical University of Lodz, Pomorska Street 251, 92-213 Lodz, Poland

Received 8 June 2014; Revised 22 July 2014; Accepted 23 July 2014; Published 11 August 2014

Academic Editor: Javier González-Gallego

Copyright © 2014 Anna Gawron-Skarbek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Whether the incidence of coronary heart disease CHD is related to a decrease in total antioxidant capacity TAC has not yet been completely clarified. We assessed TAC of blood serum in a group of 163 men with CHD aged 34.8–77.0 years and in 163 age-matched peers without CHD. Two spectrophotometric methods were applied to assess TAC: ferric reducing ability of serum TAC-FRAS and 2.2-diphenyl-1-picryl-hydrazyl TAC-DPPH tests. In the CHD group, multivariate analysis revealed that uric acid UA, triglycerides, and systolic blood pressure contributed independently to the TAC-FRAS variance. TAC-DPPH was favorably predicted by UA concentration, but negatively so by current smoking and glucose levels. In men without CHD, UA was the only independent determinant of both TAC-FRAS and TAC-DPPH. Presence of CHD was not an independent predictor of TAC—observed between-group differences higher TAC in CHD patients disappeared after adjustment for other confounders. We conclude that UA is the main determinant of TAC of blood serum in men. TAC is not directly influenced by age or CHD but is related to several indices of overweight-obesity and laboratory measures of metabolic syndrome, especially in patients with CHD.





Author: Anna Gawron-Skarbek, Jacek Chrzczanowicz, Joanna Kostka, Dariusz Nowak, Wojciech Drygas, Anna Jegier, and Tomasz Kostka

Source: https://www.hindawi.com/



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