Initial In Vivo Evaluation of a Novel Left Ventricular Assist DeviceReport as inadecuate




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BioMed Research International - Volume 2015 2015, Article ID 148579, 7 pages -

Research Article

Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

CH Biomedical Incorporation, Jiangsu 215125, China

Received 18 May 2015; Accepted 27 July 2015

Academic Editor: Tamer Mohamed

Copyright © 2015 Guanghui Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the study was to use the ovine model to evaluate the hemocompatibility and end-organ effects of a newly developed magnetic suspension centrifugal left ventricular assist device LVAD by CH Biomedical Inc., Jiangsu, China. The LVADs were implanted in 6 healthy sheep, where inflow was inserted into the left ventricular apex and outflow was anastomosed to the descending aorta. All sheep received anticoagulation and antiaggregation therapy during the study. Hematologic and biochemical tests were performed to evaluate anemia, hepatorenal function, and the extent of hemolysis. The experiments lasted for up to 30 days on the beating hearts. All sheep were humanely killed at the termination of the experiments, and the end-organs were examined macroscopically and histopathologically. Autopsy was performed in all animals and there was no thrombus formation observed inside the pump. The pump’s inflow and outflow conduits were also free of thrombus. Hematologic and biochemical test results were within normal limits during the study period. Postmortem examination of the explanted organs revealed no evidence of ischemia or infarction. Based on the in vivo study, this LVAD is suitable for implantation and can provide efficient support with good biocompatibility. The encouraging results in this study suggest that it is feasible to evaluate the device’s long-term durability and stability.





Author: Guanghui Wu, Changyan Lin, Haiyang Li, Xiaotong Hou, Chen Chen, Xiujian Liu, Chuangye Xu, Jing Wang, Peng Yang, and Wenbo

Source: https://www.hindawi.com/



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