Ethnic differences in the 405 and −460 vascular endothelial growth factor polymorphisms and peripheral neuropathy in patients with diabetes residing in a North London, community in the United KingdomReport as inadecuate




Ethnic differences in the 405 and −460 vascular endothelial growth factor polymorphisms and peripheral neuropathy in patients with diabetes residing in a North London, community in the United Kingdom - Download this document for free, or read online. Document in PDF available to download.

BMC Neurology

, 17:125

Neuromuscular disorders and peripheral neurology

Abstract

BackgroundThere are marked ethnic differences in the susceptibility to the long-term diabetic vascular complications including sensory neuropathy. The vascular endothelial growth factor VEGF +405 C-G and −460 T-C polymorphisms are associated with retinopathy and possibly with nephropathy, however no information is available on their relationship with peripheral neuropathy. Therefore, we examined the prevalence of these VEGF genotypes in a multi-ethnic cohort of patients with diabetes and their relationship with evident peripheral diabetic neuropathy.

MethodsIn the current investigation, we studied 313 patients with diabetes mellitus of African-Caribbean, Indo-Asian and Caucasian ethnic origin residing in an inner-city community in London, United Kingdom attending a single secondary care centre. Genotyping was performed for the VEGF +405 and VEGF −460 polymorphisms using a pyrosequencing technique.

ResultsForty-nine patients 15.6% had clinical evidence of peripheral neuropathy. Compared to Caucasian patients, African-Caribbean and Indo-Asian patients had lower incidence of neuropathy 24.6%, 14.28%, 6.7%, respectively; P = 0.04. The frequency of the VEGF +405 GG genotype was more common in Indo-Asian patients compared to African-Caribbean and Caucasian patients 67.5%, 45.3%, 38.4%, respectively; p ≤ 0.02. The G allele was more common in patients with type 2 diabetes of Indo-Asian origin compared to African-Caribbean and Caucasian origin p ≤ 0.02. There was no difference between the ethnic groups in VEGF −460 genotypes. The distributions of the VEGF +405 and VEGF −460 genotypes were similar between the diabetic patients with and without neuropathy.

ConclusionsIn this cohort of patients, VEGF +405 and VEGF −460 polymorphisms were not associated with evident diabetic peripheral neuropathy, however an association was found between VEGF +405 genotypes and Indo-Asian which might have relevance to their lower rates of ulceration and amputation. This finding highlights the need for further investigation of any possible relationship between VEGF genotype, circulating VEGF concentrations and differential vulnerability to peripheral neuropathy amongst diabetic patients of different ethnic backgrounds.

KeywordsDiabetes Peripheral neuropathy Ethnicity VEGF Gene polymorphism Pyrosequencing Microvascularization AbbreviationsPCRPolymerase chain reaction

VEGFVascular Endothelial Growth Factor

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Author: Karima Zitouni - Lorna Tinworth - Kenneth Anthony Earle

Source: https://link.springer.com/







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