Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal Erignathus barbatusReport as inadecuate




Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal Erignathus barbatus - Download this document for free, or read online. Document in PDF available to download.

Case Reports in Veterinary Medicine - Volume 2014 2014, Article ID 103279, 4 pages -

Case Report

CSU Veterinary Diagnostic Medicine Center, Fort Collins, CO, USA

North Slope Borough Department of Wildlife Management, Barrow, AK, USA

Indiana Animal Disease Diagnostic Laboratory and Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA

Colorado State University Veterinary Diagnostic Laboratory, 300 West Drake Avenue, Fort Collins, CO 80526, USA

Received 30 May 2014; Accepted 13 August 2014; Published 31 August 2014

Academic Editor: Luciano Espino López

Copyright © 2014 G. Krafsur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists. A case of multiple firm white nonencapsulated nodules in the heart of a bearded seal is described. Microscopic findings included cytoplasmic vacuolization with formation of spider cells, glycogen vacuoles, and striated myofibrils. These cells expressed immunoreactivity for neuron-specific enolase and protein gene product 9.5, a marker for neuronal tissue and Purkinje fiber cells. Immunoreactivity for protein gene product 9.5 along with other microscopic findings substantiates Purkinje fiber cell origin of the cardiac rhabdomyoma in the bearded seal and use of the term purkinjeoma to describe this lesion.





Author: G. Krafsur, E. J. Ehrhart, J. Ramos-Vara, G. Mason, F. Sarren, B. Adams, C. Hanns, T. Spraker, and C. Duncan

Source: https://www.hindawi.com/



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